Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity.

Ammonium salts as economical and eco-friendly N-sources applied to green, simple and scale-up synthesis of trialkyl amines in water

We have introduced a selective synthesis of tertiary amines using alkyl halide and ammonium salts as the amine sources in water. This green process has outstanding superiorities, such as being eco-friendly, possessing ammonium salts, and using water as a green solvent in the absence of organic ligands or catalysts. It is worth mentioning that the presence of t-Butyl alcohol and potassi...

Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.

Dynamin is a GTPase enzyme involved in membrane constriction and fission during endocytosis. Phospholipid binding via its pleckstrin homology domain maximally stimulates dynamin activity. We developed a series of surface-active small-molecule inhibitors, such as myristyl trimethyl ammonium bromide (MiTMAB) and octadecyltrimethyl ammonium bromide (OcTMAB), and we now show MiTMAB targets the dyna...

In vitro inhibition of diphtheria toxin action by ammonium salts and amines.

Kim, K. (University of Washington, Seattle), and N. B. Groman. In vitro inhibition of diphtheria toxin action by ammonium salts and amines. J. Bacteriol. 90:1552-1556. 1965.-An inhibitor for diphtheria toxin action on HeLa cells was demonstrated in the growth supernatant fractions of both toxinogenic and nontoxinogenic strains of Corynebacterium diphtheriae and in the Mueller and Miller medium ...

Long-term, high-dose aspirin therapy increases the specific activity of complex III of mitochondrial respiratory chain in the kidney of diabetic rats

Introduction: One of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. Aspirin (ASA) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. The aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

The respiration of rat-liver slices in the presence of some aliphatic amines, hydroxyamines and quaternary ammonium salts.